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KMID : 1098420160240060471
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Korean Journal of Medicinal Crop Science
2016 Volume.24 No. 6 p.471 ~ p.478
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Effect of Roasted Water Extract of Fermented Cassia tora L. by Lactobacillus casei on the Loperamide-Induced Constipation Model in Rats
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Nho Jong-Hyun
Jung Ho-Kyung
Lee Mu-Jin
Jang Ji-Hun
Sim Mi-Ok
Jung Ja-Kyun
Lee Ki-Ho
An Byeong-Kwan
Cho Jung-Hee
Jang Min-Cheol
Yong Ju-Hyun
Cho Hyun-Woo
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Abstract
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Background: Constipation is one of the most common functional gastrointestinal disorder. The present study examined the ability of water extract of fermented (FRC) and non-fermented (NFRC) roasted Cassia tora to improve intestinal function and reduce constipation in a rat constipation model.
Methods and Results: Different concentration of FRC and NFRC were orally administered loperamide (5 mg/kg; LOP) reduced the number, weight, and water content of feces, as well as intestinal transit motility. However, 24 h-(24 hour fermented roasted-Cassia tora) 300 mg/kg FRC administration increased the number, weight, and water concent of feces, compared to that seen in the LOP group, and also improve intestinal transit mitility and, the thickness of distal colon and mucous fluid.
Conclusions: The results of the present study indicated that LOP-induced constipation was improved by treatment with FRC. Therefore FRC could be used to develop functional foods or natural medicine for constipation. However, further study is needed to clarify how fermentation improves the medicinal properties of roasted C. tora.
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KEYWORD
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Cassia tora L., Cassiae semen, Constipation, Laxative, Loperamide
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